Probiotics reduce piglet pathogensPiglets fed probiotic Enterococcus faecium showed reduced numbers of potentially pathogenic Escherichia coli strains in their intestines according to a team of German researchers. The research is important because in 2006 the European Union prohibited the feeding of antibiotics to livestock as growth promoters. Therefore the research team sought to investigate whether probiotics could substitute for antibiotics by reducing pathogen populations in the intestines says first author Carmen Bednorz of Freie Universitat Berlin Germany. The study was published ahead of print in the journal Applied and Environmental Microbiology.We found a clear reduction of E. coli strains possessing typical genes for extra-intestinal pathogenic E. coli (ExPEC) says Bednorz. The reduction was particularly noticeable in strains that adhere to the intestinal mucosa (and less so in the feces) which was very interesting she says because ExPEC typically harbor a lot of adhesion genes that promote colonization of the mucosa.Antimicrobials are thought to promote growth in industrially grown livestock because without them the rationale goes in such close quarters a surfeit of pathogens would slow growth. Our data suggest that the feeding of probiotics could substitute for antimicrobials as growth promoters says Bednorz. This could help to reduce the burden of antimicrobial resistance she adds.In previous studies the working groups from the Institute of Microbiology and Epizootics at Freie Universitat Berlin found that feeding E. faecium probiotic did not change the general swine intestinal microbiota but reduced infections by Chlamydia spp. and pathogenic E. coli according to the report.In the study Bednorz and her collaborators compared piglets fed with E. faecium to those in a control group. They collected more than 1400 samples of E. coli from piglets of different ages and from different parts of the intestine.While a number of strains of E. coli are pathogenic non-pathogenic E. coli contributes to the maintenance of the microbial gut balance according to the report. These were relatively unaffected by the feeding of E. faecium which did not influence the overall intestinal E. coli diversity corroborating previous data according to the report. Thus the researchers conclude the results suggest that E. faecium inhibits pathogenic E. coli from becoming attached to the intestinal mucosa.Story Source:The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.Journal Reference: